Exposure to 50 Hz electromagnetic fields enhances hair follicle regrowth in C57BL/6 miceXinping Li et al. Exp Biol Med (Maywood). 2019 Apr. Show
Free PMC article AbstractIn this study, our experiments confirmed that 50 Hz EMF affected hair follicle regrowth, and 50 Hz EMF enhanced K15+ stem cells proliferation in the hair bulb and follicular outer root sheath of hair follicles. Those results indicated that 50 Hz EMF may be beneficial for functional healing of hair loss. Keywords: Electromagnetic field; epidermal stem cells; hair growth; keratinocyte growth factor. FiguresFigure 1. Effects of 50 Hz EMF on hair follicle regrowth. The morphogenesis of the hair follicle was photographed. EMF group (a, c, e) vs. control (b, d, f). H&E staining showed that, compared to the control, the hair club formed earlier in the EMF group than the control on the 3rd day after depilation (green arrow) (a) and most of the hair shafts had erupted from the pore in the epidermis in the EMF group on the 9th day after depilation (red arrow) (c). EMF group (a with magnification 10×, c, e with magnifications 4×) vs. control (b with magnification 10×, d, f with magnifications 4×). Bars 100 μm. (A color version of this figure is available in the online journal.) Figure 2.Quantification analysis of the hairs length. Twenty hairs were measured on the 9th, 16th day of the experiment. Data presented as means ± SD. *P < 0.05, compared with control (t-test). Figure 3.The influence of 50 Hz EMF on the development of anagen hair follicles. K15+ cells were expressed not only in cells of the bulge but also in the basal layer of the epidermis. More K15+ cells are expressed in cells of the follicular bulge in 50 Hz EMF group compared to the control group. Control (a, c, e with magnifications 4×) vs. EMF group (b, d, f with magnifications 4×). Bars 100 μm. (A color version of this figure is available in the online journal.) A comparable percentage of Ki67-positive cells were detected in 50 Hz EMF group and control group. The percentage of proliferating cells was higher than controls between dermal papilla and hair bulb in mice on the 3rd day, and in the ORS on the 9th and 16th day (arrow). Control (a, c, e with magnifications 4×) vs. EMF group (b, d, f with magnifications 4×). Bars 100 μm. (A color version of this figure is available in the online journal.) Figure 5.Immunofluorescence staining analysis of KGF protein localization on the skin during hair follicle regrowth. KGF expression was seen in the cells of the inner root sheath in both groups on the 9th and 16th day of the experiment (arrow). Bars 100 μm. All magnifications 4×. (A color version of this figure is available in the online journal.) Figure 6.The expression of KGF proteins in the development process of the new hairs. KGF expression increased gradually and then waned at a later anagen phase. There was a higher level of KGF expression after EMF exposure. The difference of KGF expression between the two groups was first identified on the 3rd day of the experiment. Similar articles
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