Can you take azithromycin and fluconazole together

Background: Azithromycin, fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole; TMP/SMX) are all agents that are utilised for the treatment and/or prophylaxis of opportunistic infections in patients with AIDS.

Objective: To characterise the potential for an interaction when azithromycin is coadministered with cotrimoxazole or with fluconazole.

Design: Two separate nonblind randomised studies were conducted in healthy volunteers. During the fluconazole study the potential for fluconazole to adversely affect the pharmacokinetics of azithromycin was also studied.

Participants: 24 (cotrimoxazole) and 18 (fluconazole) healthy male and female volunteers.

Results: The results of both studies indicated that neither the peak concentrations of nor the exposures (area under the concentration-time curve) to the test drugs were changed when azithromycin was coadministered. In addition, fluconazole did not significantly alter the pharmacokinetic parameters of azithromycin.

Conclusions: Azithromycin does not alter the bioavailability of either cotrimoxazole or fluconazole.

Azithromycin/QT Prolonging Agents Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Azithromycin can affect your heart's rhythm. Other drugs can have the same effect.

What might happen:

Taking azithromycin with other agents that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening.

What you should do about this interaction:

Let your healthcare professionals (e.g doctor or pharmacist) know that you are taking these medications together. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

A 46-year-old member asked:

2 doctor answers2 doctors weighed in

Can you take azithromycin and fluconazole together

Internal Medicine - Geriatrics 22 years experience

4.7k viewsAnswered >2 years ago

Can you take azithromycin and fluconazole together

Pharmacology 18 years experience

Fine together: These medications are not known to not negatively interact, so taking them together should be fine.

1.4k viewsAnswered >2 years ago

Last updated May 24, 2022

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Disclaimer:

Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.

Can I take azithromycin while taking fluconazole?

Conclusions: Azithromycin does not alter the bioavailability of either cotrimoxazole or fluconazole.

What medications should not be taken with fluconazole?

Many drugs can interact and cause dangerous effects..
cisapride, fentanyl, methadone, pimozide, tofacitinib, tolvaptan, or a vitamin A supplement;.
an antibiotic, antifungal, or antiviral medicine;.
a blood thinner;.
cancer medicine;.
cholesterol medication;.

Is fluconazole same as azithromycin?

Azithromycin is an antibiotic that works by inhibiting bacterial protein synthesis, which further inhibits bacterial growth. Fluconazole is an antifungal drug that stops fungi growth by causing damage and leakage to the fungal cell membrane.

Can you take fluconazole with other antibiotics?

They may prescribe an oral antifungal pill called fluconazole Diflucan for you to take during your course of antibiotics. You might be instructed to take one pill on the first day and another pill every seven days until you finish the antibiotics.