Show SummaryRead the full fact sheet
This page has been produced in consultation with and approved by: This page has been produced in consultation with and approved by: Related information
Support groupsFrom other websitesContent disclaimerContent on this website is provided for information purposes only. Information about a therapy, service, product or treatment does not in any way endorse or support such therapy, service, product or treatment and is not intended to replace advice from your doctor or other registered health professional. The information and materials contained on this website are not intended to constitute a comprehensive guide concerning all aspects of the therapy, product or treatment described on the website. All users are urged to always seek advice from a registered health care professional for diagnosis and answers to their medical questions and to ascertain whether the particular therapy, service, product or treatment described on the website is suitable in their circumstances. The State of Victoria and the Department of Health shall not bear any liability for reliance by any user on the materials contained on this website. Type 2 diabetes, formerly known as adult-onset diabetes, accounts for up to 95% of diabetes cases and is mostly the result of obesity and a lack of exercise. However, there are other causes and risk factors that contribute to this form of diabetes. This article explains what type 2 diabetes is and lists the seven common factors that can increase the risk of a disease that currently affects over 34 million adults and children in the United States. What Is Type 2 Diabetes?Type 2 diabetes is a type of diabetes characterized by high blood glucose (sugar), insulin resistance, and a relative lack of insulin. Glucose is the body's main form of energy, and insulin is the hormone produced by the pancreas that helps regulate glucose levels in the blood. When insulin levels are low and/or the body fails to respond to the effects of insulin (insulin resistance), blood sugar levels can increase out of control. Over time, persistently high glucose levels, referred to as hyperglycemia, can damage the blood vessels, nerves, kidneys, eyes, skin, brain, and other organs. Type 2 diabetes is generally considered to be a lifestyle-related disease, but family history and genetics also play a major role in its development. Insulin helps transport glucose from the bloodstream with the help of glucose transporters. Lifestyle Risk FactorsWhile certain people are predisposed to type 2 diabetes due to their genetics, lifestyle plays the predominant role in the onset of the disease. In short, having a genetic disposition for type 2 diabetes does not mean you will get it. The choices you make with respect to diet and exercise can ultimately determine if you get the disease or not. Diet, Exercise, and ObesityThe number one risk factor for type 2 diabetes is being overweight or obese. A person is considered overweight when their body mass index (BMI) is over 25 and obese when their BMI is over 30. Today, over 140 million adults and over 14 million children in the United States have obesity. The main symptom of obesity is excessive body fat, which increases the level of fatty acids in the blood. As these fats accumulate in the liver, the function of the liver becomes increasingly impaired. And, one of its main functions is the production and storage of glucose. Obesity triggers the onset of insulin resistance which, in turn, contributes to the onset of type 2 diabetes. Risk factors for obesity and being overweight include:
Body Mass IndexBMI uses weight and height to try and estimate body fat. The resulting number is then used to categorize people as underweight, normal weight, overweight, obese, or morbidly obese. BMI is not perfect, however, and does not account for other factors that determine body composition like age, muscle mass, or sex. BMI calculations may, for example, overestimate body fat in athletes or in older people. Lack of SleepFor reasons that are not entirely clear, studies have shown that a lack of sleep is associated with a significant increase in the risk of type 2 diabetes. It is thought the lack of sleep increases the production of the stress hormone cortisol. While cortisol can help keep you awake, having too much can dampen the production of insulin as well as the body's response to insulin. As such, a chronic lack of sleep is considered by some to be a contributing risk factor for type 2 diabetes. Older AgeThe older we get, the greater the risk of insulin resistance and type 2 diabetes. This is thought to be due to aging-related changes to the pancreas that reduce its ability to produce and secrete insulin. Aging liver cells, called hepatocytes, may also become less sensitive to insulin and be less able to regulate blood sugar levels. Type 2 diabetes most often affects people over 45, but more children, teens, and young adults are developing it due to unhealthy dietary and lifestyle habits. GeneticsHaving family members with type 2 diabetes increases your risk of type 2 diabetes. Some studies have shown that having a mother or father with type 2 diabetes can increase your risk of the disease by up to threefold. With that said, it is no guarantee that you will get the disease. Scientists have thus far identified more than 120 gene mutations associated with type two diabetes. Even so, the relationship between these mutations and the risk of type 2 diabetes is inconsistent. In fact, there are very few single-gene mutations linked to type 2 diabetes. Most cases involve multiple gene mutations, and all almost invariably require lifestyle factors such as poor diet, lack of exercise, and obesity for type 2 diabetes to develop. Because families tend to have similar dietary and lifestyle habits, the familial link to type 2 diabetes is thought to be influenced more by lifestyle than by genes. Race and EthnicityRace and ethnicity can also factor into a person's risk of type 2 diabetes, with people of color disproportionately affected. While culture and lifestyle certainly play a part, some studies suggest the risk goes well beyond just weight or exercise. According to a 2019 study from the Centers for Disease Control and Prevention (CDC), the rate of type 2 diabetes among racial/ethnic groups in the United States broke down as follows:
Metabolic Risk FactorsHypertension (high blood pressure) and hyperlipidemia (high cholesterol) are hallmark risk factors for many diseases, including type 2 diabetes.Not only do these conditions contribute to the risk of heart disease, stroke, and chronic kidney disease (CKD), but they are also central components of metabolic syndrome. Metabolic syndrome is a cluster of at least three of the following medical conditions:
Studies suggest that metabolic syndrome increases the risk of type 2 diabetes by five-fold compared to people without metabolic
syndrome. A Word From VerywellSome risk factors for diabetes such as family history and genetic predisposition may be out of your control, but there's still a lot you can do to help manage your blood sugar and prevent the disease from progressing. The key is to fully embrace a healthy lifestyle: Work with a nutritionist to make sure you're getting plenty of fiber, healthy fats, and the right nutrients, and find a personal trainer to help you get a fitness regimen that works with your abilities and schedule. And don't forget about getting plenty of sleep and reducing your stress levels, too, as stress may also play a role in keeping blood sugar balanced. Frequently Asked Questions
|