Figure 1. This stained slide shows the two components of the dermis—the papillary layer and the reticular layer. Both are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer. LM × 10. (credit: modification of work by “kilbad”/Wikimedia Commons) Show
The dermis might be considered the “core” of the integumentary system (derma- = “skin”), as distinct from the epidermis (epi– = “upon” or “over”) and hypodermis (hypo– = “below”). It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that compose an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts (Figure 1). Papillary LayerThe papillary layer is made of loose, areolar connective tissue, which means the collagen and elastin fibers of this layer form a loose mesh. This superficial layer of the dermis projects into the stratum basale of the epidermis to form finger-like dermal papillae (see Figure 1). Within the papillary layer are fibroblasts, a small number of fat cells (adipocytes), and an abundance of small blood vessels. In addition, the papillary layer contains phagocytes, defensive cells that help fight bacteria or other infections that have breached the skin. This layer also contains lymphatic capillaries, nerve fibers, and touch receptors called the Meissner corpuscles. Reticular LayerUnderlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective tissue. This layer is well vascularized and has a rich sensory and sympathetic nerve supply. The reticular layer appears reticulated (net-like) due to a tight meshwork of fibers. Elastin fibers provide some elasticity to the skin, enabling movement. Collagen fibers provide structure and tensile strength, with strands of collagen extending into both the papillary layer and the hypodermis. In addition, collagen binds water to keep the skin hydrated. Collagen injections and Retin-A creams help restore skin turgor by either introducing collagen externally or stimulating blood flow and repair of the dermis, respectively. The dermis is the second and thickest layer of the three major layers of skin, located between the epidermis and subcutaneous tissues, also known as the subcutis and the hypodermis. The skin was previously viewed as a body part that protects us from the elements. Today, new knowledge informs us that the layers of the skin are actually very complex and have many important functions—from giving us goosebumps and cooling us down in the sauna to letting our brain know that our hand is on a burner. Let's learn more about how this layer is structured and what it does for us. Anatomy and StructureThe dermis has two parts: a thin, upper layer known as the papillary dermis, and a thick, lower layer known as the reticular dermis. Its thickness varies depending on the location of the skin. For example, the dermis on the eyelids is 0.6 millimeters thick; on the back, the palms of hands and the soles of feet, it measures 3 millimeters thick. The dermis contains a lot of the body's water supply and it has important roles in both regulating temperature and providing blood to the epidermis. Structures found in the dermis include:
Tissue CompositionThe dermis is composed of three types of tissues that are present throughout the dermis rather than in layers:
The papillary layer, the upper layer of the dermis, contains a thin arrangement of collagen fibers. The lower layer, known as the reticular layer, is thicker and made of thick collagen fibers that are arranged parallel to the surface of the skin. Roles It PlaysThe dermis is the thickest layer of skin and arguably the most important. It plays several key roles, including:
Interactions With the EpidermisNot only does the dermis have complex functions, but it is in constant contact and communication with the epidermis, regulating important bodily processes. Cells in the epidermis influence the dermis, which in turn influence the turnover of cells in the epidermis (via activities of cells such as mast cells, which secrete cytokines). It is the interaction of these two layers that is, in fact, most disrupted in some conditions such as psoriasis. Aging ProcessMany people wonder about what causes the skin to wrinkle and age. There are several important changes in all three layers of our skin as we age. The dermal layer becomes thinner with age as less collagen is produced. Elastin wears out—becoming less elastic just as the elastic waistband in a pair of shorts may lose its elasticity. This is what leads to wrinkling and sagging. The sebaceous glands produce less sebum while the sweat glands produce less sweat, both contributing to the skin dryness characteristic of aging. The surface area or amount of contact between the dermis and epidermis also decreases. This results in less blood being made available from the dermis to the epidermis and fewer nutrients making it to this outer layer of skin. This flattening out of the connecting region also makes the skin more fragile. Causes and Risk Factors of Wrinkles TumorsJust as abnormal growths in the epidermis give rise to the all-too-common skin cancers, tumors can arise from the dermal layer of the skin as well. One type of tumor which begins in the dermis is called a dermatofibroma (or benign fibrous histiocytoma.) These fairly common tumors often occur on the legs of middle-aged women. It's not known what exactly causes these tumors, but they frequently occur following some form of trauma. ProtectionJust as it's important to protect your epidermis from too much sun, it's important to protect your dermis as well. Sun exposure damages collagen (and causes changes in elastin), which can result in premature wrinkling. Frequently Asked Questions
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