Quick look:A nuclear pore is a minute opening or passage way through the nuclear envelope. It connects the nucleoplasm (nucleus) with the cytoplasm. The opening is ‘plugged’ with an amazing biological valve that only permits selected chemicals to move into and out of the nucleus. Show NUCLEAR PORE – Perforations with purpose
Nuclear Pore – an operating analogy The turnstile therefore not only controls the flow but is also selective. The ticket operating the turnstile, like certain proteins entering a nuclear pore, carries important destination information. It might be something like “Porham Stadium, Stand 4, Row E, Seat 32”. Without this detailed information access is denied. In cell biology terms this entry information consists of a short protein sequence called a ‘nuclear localisation signal’. Some viruses use ‘counterfeit tickets’ to gain access Why is a nuclear pore complex needed? Imports to the nucleus Small water-soluble molecules and proteins of small molecular weight can pass through the pore unchallenged and unaccompanied. Export from the nucleus Big lay-off at cell division SUMMARY
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