What does passing fibroid tissue look like

Ischemic Complications

Ischemia (blockage of blood flow) is the intended result of embolization, depriving the fibroids of blood, oxygen, and nutrients. The uterus and/or ovaries are also potentially affected, although they have the capacity to recover and the fibroids do not.

Pelvic pain

Crampy pelvic pain occurs in almost every patient following UFE. Rarely, someone will have no pain. It is important to remember that the presence or severity of pain is not correlated with clinical failure or success. Pain is usually moderate to severe, sometimes as severe as labor pain. The pain after UFE usually peaks within hours of the procedure, but may occasionally be severe even into the second day, and rarely the third day or later. Most pain will usually be gone within a few days and rarely will it require more than a week to completely resolve.

Fever

Up to 1/3 of patients will have a temperature of 100.4°F or higher following embolization as part of a well-known post-embolization syndrome. You have been given a prescription for a medication that will prevent your temperature from reaching uncomfortable levels. Fever is only worrisome if it is associated with chills or is higher than 101.5°F and fails to respond to aspirin or Tylenol. Please contact us immediately if this occurs.

Nausea/vomiting

Nausea and/or vomiting are not uncommon following the procedure. Again, you have been given medications to help prevent this or treat it if it occurs.

Fibroid sloughing

In the weeks that follow UFE, approximately 5% of patients will pass fragments of necrotic (dead) fibroids, or even a whole fibroid. It is more likely to occur when the fibroids are submucosal. Your doctor will discuss whether this is the case with you. Passage of fibroid material can happen as late as 8 to 10 weeks afterward and occasionally even after that. Sloughing of a fibroid is often experienced as a sudden onset of intense crampy pain and an odorous vaginal discharge. In most cases it will pass within 36 to 48 hours, with prompt resolution of symptoms. The positive side of this is that there is often a noticeable reduction in uterine size and improvement in bulk-related symptoms. If the piece of fibroid does not pass on its own after a day or two, you may require a procedure to help remove it.

Non-target embolization

Non-target embolization occurs when the embolic agent passes into a circulation other than where it is intended; with UFE that would be outside the uterus. The ovary shares blood supply with the uterus in many women and is the organ most frequently affected by non-target embolization. Premature menopause or permanent loss of menses (periods) can occur in up to 5% of patients. It rarely occurs in women who are under 45 years of age. Approximately 5-10% of women have a decrease or even transient loss of menses, but their periods will return, usually lighter than before. Hot flashes and/or other menopausal symptoms may accompany this. Other, more rare examples of non-target embolization would be occlusion of adjacent branches such as to the bladder or rectum. Such instances have not been reported for UFE.

Fertility

As discussed above, some patients may experience premature ovarian failure. However, many patients have become pregnant and delivered health babies after UFE. Statistics on the affects of UFE on fertility are not known.

Sexual dysfunction

Approximately 15% of women normally report having sensations of strong uterine contractions during orgasm. There is one case report in the world literature describing a woman who lost this sensation following UFE. The authors of the case report hypothesized that this might have been related to non-target embolization of the cervix and/or the adjacent neural plexus. However, there were three studies on sexuality after UFE presented at a recent scientific meeting, which found no change and even an improvement in sexual experience after UFE. 

To date, there have been no reports of birth defects or intrauterine growth retardation. A note of caution should be made: there is one anecdotal case of a woman who had uterine rupture during labor at a point of weakness in the uterine wall where a transmural (through-the-wall) fibroid had infracted (died).

Overview

What are uterine fibroids? A Mayo Clinic expert explains

Learn more about uterine fibroids from Michelle Louie, M.D., a minimally invasive gynecologic surgeon at Mayo Clinic.

I'm Dr. Michelle Louie, a minimally invasive gynecologic surgeon at Mayo Clinic. In this video, we'll cover the basics of uterine fibroids. What is it? Who gets it? The symptoms, diagnosis, and treatment. Whether you're looking for answers for yourself or someone you love. We're here to give you the best information available. Uterine fibroids, also called leiomyomas or myomas, are growths that appear in the uterus. They're made of uterine muscle. They're noncancerous and extremely common. In fact, 75 to 80% of people with a uterus will be diagnosed with fibroids at some point in their lives. These growths often show up during the reproductive years, most commonly in your 20s to 30s. They can range in quantity, size and growth rate. So each case is a bit different.

Who gets it?

We believe uterine fibroids occur when one cell of muscle divides repeatedly to create a firm, rubbery mass of tissue. Scientists are not yet sure exactly what sparks this behavior, but we're looking into specific genes. We do know a couple of risk factors that may make someone more likely to get fibroids. First, race. For reasons that are unclear, fibroids are more prevalent and more severe among black patients compared to other racial groups. Second, family history. If your mother or sister had fibroids, you're at increased risk for developing them, too. And more studies look into other risk factors like obesity, lifestyle choices, and diet.

What are the symptoms?

Most people with fibroids don't have symptoms at all. That's why they're often found unintentionally during a routine checkup. If a patient does have symptoms, heavy, prolonged, or painful menstrual bleeding is a common problem. Periods that lasts more than one week or cause soaking through pads or tampons every hour or large blood clots are also considered abnormal. If fibroids get very large, they can cause your belly to bulge like a pregnancy or press on nearby organs causing constant pelvic pressure, frequent urination, or difficulty passing bowel movements. In some cases, fibroids can make it harder to get pregnant or cause problems during pregnancy or childbirth. If you're experiencing any of these symptoms, talk to your doctor.

How is it diagnosed?

Fibroids are often found during a routine pelvic exam. If your doctor feels an irregularity in the shape of the uterus or if you come in with symptoms, they'll probably order a diagnostic test like an ultrasound. Beyond that, your doctor may need more information, especially if you're trying to get pregnant or at risk for uterine cancer. They might order blood tests or imaging studies like an MRI. Sometimes other unique imaging studies that use water to see inside the uterus or dye to check the fallopian tubes are needed if you're trying to get pregnant. Even hysteroscopy, in which a small camera is guided through the vagina, is sometimes used to see inside the uterus where some fibroids can be located. All these tests are done in service of getting a better, clearer picture of what's going on or to check for other problems.

How is it treated?

There are many ways in which we treat uterine fibroids. If you have no or only mild symptoms, as many women do, the best treatment may be no treatment at all. We call this watchful waiting where we keep a careful eye on your fibroids until further action is needed. Medication or birth control is another option which can relieve symptoms like heavy, irregular or painful periods. For some more severe cases, surgery may be needed. The kind of surgery we recommend depends on the size, number, and location of fibroids, as well as your personal goals, feelings about pregnancy and surgery, and general health. A hysterectomy is where the uterus and the fibroids are removed together. And it is a great option for those who have no desire for pregnancy as it guarantees no more period bleeding and the fibroids cannot return in the future. A myomectomy is a surgery in which we remove the fibroids through the vagina or the abdominal wall. Uterine fibroid embolization is a more minor procedure in which we blocked the blood supply to the fibroids, causing them to shrink but not go away completely. A radiofrequency fibroid ablation is where a probe is inserted into the fibroid and heats the tissue, so it shrinks. Magnetic resonance-guided focused ultrasound passes energy through the abdomen to destroy the fibroid. Lastly, an endometrial ablation is a procedure in which a device is inserted through the vagina to treat the uterine lining, and stop heavy period bleeding due to fibroids. But this does not treat the fibroids themselves.

What now?

Fibroids are common, noncancerous and often don't need treatment. Whether or not you do end up needing treatment, know that there are many options that can address your concerns and give you a great quality of life. Talk to your doctor or get a referral to a fibroid specialist to ensure that you are offered all the treatment options. If you'd like to learn more about fibroids, watch our other related videos, or visit mayoclinic.org. We wish you well.

Uterine fibroids are noncancerous growths of the uterus that often appear during childbearing years. Also called leiomyomas (lie-o-my-O-muhs) or myomas, uterine fibroids aren't associated with an increased risk of uterine cancer and almost never develop into cancer.

Fibroids range in size from seedlings, undetectable by the human eye, to bulky masses that can distort and enlarge the uterus. You can have a single fibroid or multiple ones. In extreme cases, multiple fibroids can expand the uterus so much that it reaches the rib cage and can add weight.

Many women have uterine fibroids sometime during their lives. But you might not know you have uterine fibroids because they often cause no symptoms. Your doctor may discover fibroids incidentally during a pelvic exam or prenatal ultrasound.

Symptoms

Many women who have fibroids don't have any symptoms. In those that do, symptoms can be influenced by the location, size and number of fibroids.

In women who have symptoms, the most common signs and symptoms of uterine fibroids include:

  • Heavy menstrual bleeding
  • Menstrual periods lasting more than a week
  • Pelvic pressure or pain
  • Frequent urination
  • Difficulty emptying the bladder
  • Constipation
  • Backache or leg pains

Rarely, a fibroid can cause acute pain when it outgrows its blood supply, and begins to die.

Fibroids are generally classified by their location. Intramural fibroids grow within the muscular uterine wall. Submucosal fibroids bulge into the uterine cavity. Subserosal fibroids project to the outside of the uterus.

When to see a doctor

See your doctor if you have:

  • Pelvic pain that doesn't go away
  • Overly heavy, prolonged or painful periods
  • Spotting or bleeding between periods
  • Difficulty emptying your bladder
  • Unexplained low red blood cell count (anemia)

Seek prompt medical care if you have severe vaginal bleeding or sharp pelvic pain that comes on suddenly.

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Causes

Doctors don't know the cause of uterine fibroids, but research and clinical experience point to these factors:

  • Genetic changes. Many fibroids contain changes in genes that differ from those in typical uterine muscle cells.
  • Hormones. Estrogen and progesterone, two hormones that stimulate development of the uterine lining during each menstrual cycle in preparation for pregnancy, appear to promote the growth of fibroids.

    Fibroids contain more estrogen and progesterone receptors than typical uterine muscle cells do. Fibroids tend to shrink after menopause due to a decrease in hormone production.

  • Other growth factors. Substances that help the body maintain tissues, such as insulin-like growth factor, may affect fibroid growth.
  • Extracellular matrix (ECM). ECM is the material that makes cells stick together, like mortar between bricks. ECM is increased in fibroids and makes them fibrous. ECM also stores growth factors and causes biologic changes in the cells themselves.

Doctors believe that uterine fibroids develop from a stem cell in the smooth muscular tissue of the uterus (myometrium). A single cell divides repeatedly, eventually creating a firm, rubbery mass distinct from nearby tissue.

The growth patterns of uterine fibroids vary — they may grow slowly or rapidly, or they may remain the same size. Some fibroids go through growth spurts, and some may shrink on their own.

Many fibroids that have been present during pregnancy shrink or disappear after pregnancy, as the uterus goes back to its usual size.

Risk factors

There are few known risk factors for uterine fibroids, other than being a woman of reproductive age. Factors that can have an impact on fibroid development include:

  • Race. Although all women of reproductive age could develop fibroids, black women are more likely to have fibroids than are women of other racial groups. In addition, black women have fibroids at younger ages, and they're also likely to have more or larger fibroids, along with more-severe symptoms.
  • Heredity. If your mother or sister had fibroids, you're at increased risk of developing them.
  • Other factors. Starting your period at an early age; obesity; a vitamin D deficiency; having a diet higher in red meat and lower in green vegetables, fruit and dairy; and drinking alcohol, including beer, appear to increase your risk of developing fibroids.

Complications

Although uterine fibroids usually aren't dangerous, they can cause discomfort and may lead to complications such as a drop in red blood cells (anemia), which causes fatigue, from heavy blood loss. Rarely, a transfusion is needed due to blood loss.

Pregnancy and fibroids

Fibroids usually don't interfere with getting pregnant. However, it's possible that fibroids — especially submucosal fibroids — could cause infertility or pregnancy loss.

Fibroids may also raise the risk of certain pregnancy complications, such as placental abruption, fetal growth restriction and preterm delivery.

Prevention

Although researchers continue to study the causes of fibroid tumors, little scientific evidence is available on how to prevent them. Preventing uterine fibroids may not be possible, but only a small percentage of these tumors require treatment.

But, by making healthy lifestyle choices, such as maintaining a healthy weight and eating fruits and vegetables, you may be able to decrease your fibroid risk.

Also, some research suggests that using hormonal contraceptives may be associated with a lower risk of fibroids.

Sept. 21, 2022

What happens when a fibroid comes out?

During and after fibroid expulsion, vaginal discharge may be present. This can develop as a result of natural expulsion or expulsion after UFE. Along with fibroid expulsion discharge, some women pass pieces of fibroid tissue or a complete expelled fibroid.

Can fibroid tissue come out?

Complete expulsion of a uterine fibroid is a rare condition that may be associated with profuse hemorrhage and can pose a risk to the patient. When it occurs during perimenopause, it can mimic several clinical conditions. Therefore, gynecologists must remain alert to make the correct diagnosis and treatment.

What are the signs of dissolving fibroid?

Acute pain: The most common symptom of a degenerating fibroid is acute pelvic pain focused on the site of the fibroid. You may experience it as a sharp pain in the abdomen accompanied by swelling. This symptom can last from a few days to a few weeks.

Can fibroids come out as clots?

Blood can coagulate in the uterus or vagina at any time throughout your period, just as it does to seal an open wound on your skin. Then, when it passes during menstruation, you see clots. But large clots, such as those that are bigger than a quarter, may indicate the presence of uterine fibroids.