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Page 2
Authors
Country
Disease
Screening tools (strategies)
Comparator
Population
Time horizon
Perspective
Discounting
Monetary units
Effectiveness outcome
ICER
Conclusion of base case
Funding
Treatment
Albright et al. [55]
USA
Group B Streptococci
Universal screening with rectovaginal swab
No screening
Women with a prior cesarean delivery and a current singleton pregnancy planning to undergo a repeat cesarean
Lifetime
Healthcare
3%
2015 USD
Neonatal QALYs
Yes
Not CE
NA
Yes
Aronsson et al. [12]
Sweden
Colorectal cancer (CRC)
1. Fecal immunochemical test (FIT) twice 2. Colonoscopy (once) 3. FIT every 2 years
4. Colonoscopy every 10 years
No Screening
60-year-old Swedish
Lifetime
Healthcare
3%
EUR (no year)
QALYs
No
All strategies were CE vs no screening
SCREESCO study
Yes
Atkin et al. [18]
UK
Colorectal cancer
13 different Sttrategies
Each other and “no colonoscopy”
Individuals with intermediate-grade adenomatous polyps
Lifetime
NHS
4%
2012–2013 GBP
QALYs, ELYs
Yes
3-yearly ongoing colonoscopic surveillance without an age cut-off is CE
Hypothetical cohort of adults admitted to the Intensive care unit.
1 year
Hospital
NA
2015 USD
QALYs
Yes
This study supports updating the standard practice to a decolonization approach.
NA
No
Williams et al. [41]
USA
Prosthetic joint infection
1. 4 swabs decolonization 2. 2 swabs
3. Nasal swab alone
No screening and decolonization
Hip and knee replacement patients
NA
Societal
NA
2016 USD
Cases of prosthetic joint infections
No
The 2-swab and universal-decolonization strategy were most CE
None
Yes
Yang et al. [54]
Taiwan
Lung cancer
1. Computed tomography (CT) 2. Radiography
No screening
Smokers between 55 and 75 years of age
Lifetime
Healthcare
3%
2013 USD
QALYs
Yes
Low-dose CT screening for lung cancer among high-risk smokers would be CE in Taiwan
Ministry of Science and Technology, and the National Cheng Kung University Hospital
Yes
Yarnoff et al. [42]
USA
Chronic kidney disease (CKD)
CKD risk scores
No screening
US population
Lifetime
Healthcare
3%
2010 USD
QALYs
Yes
CKD risk scores may allow clinicians to cost-effectively identify a broader population for CKD screening
Centers for Disease Control and Prevention
Yes
Yoshimura et al. [78]
Japan
Osteoporosis
Screening and alendronate therapy
No screening and no therapy
Postmenopausal women over 60 years
5 years
Healthcare
3%
USD (no year)
QALYs
Yes
Screening and treatment would be CE for Japanese women over 60 years.
Ministry of Education, Culture, Sports, Science and Technology
Yes
Zimmermann et al. [43]
Kenya
Cervical cancer
1. Visual inspection with acetic acid (VIA) 2. Papanicolaou smear
3. Testing for human papillomavirus (HPV)
Cryotherapy without screening
Hypothetical cohort of 38-year-old women
Lifetime
Societal
3%
2014 USD
ELYs
No
VIA was most CE unless HPV could be reduced to a single visit
NA
Yes
QALYs quality-adjusted life years, ELYs expected life years, RMB Renminbi, USD United States dollar, CAD Canadian dollar, AUD Australian dollar, EUR euro; GBP British pound, NIS Israeli new shekel, IRR Iranian rial, CNY Chinese yuan, INR Indian rupee, NOK Norwegian krone, CE cost-effective, NA not applicable