Which statement most accurately describes the process leading to the development?

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Answer the following questions and then press 'Submit' to get your score.

Question 1

Which of the following statements best describes a lead compound?

a) A compound that contains the element lead

b) A compound from the research laboratory that is chosen to go forward for preclinical and clinical trials

c) A molecule that shows some activity or property of interest and serves as the starting point for the development of a drug.

d) The first compound of a structural class of compounds to reach the market.

Question 2

Identify the kind of interactions that are typically involved in binding a drug to the binding site of a protein.

a) predominantly van der Waals interactions

b) predominantly ionic bonds

c) predominantly hydrogen bonds

d) a combination of all of the above

Question 3

Which of the following statements best describes an induced fit?

a) the process by which a binding site alters shape such that it is ready to accept a drug

b) the process by which a drug adopts the correct binding conformation before entering a binding site

c) the process by which binding of a drug to a binding site alters the shape of the binding site

d) the process by which a binding site alters the shape of the drug into the binding conformation before binding

Question 4

Which of the following descriptions most accurately describes binding sites and binding regions?

a) a binding site is part of a binding region

b) a binding region is part of a binding site

c) a binding region is the same as a binding site

d) a binding region is on a drug whereas a binding site is on a macromolecular target

Question 5

Which of the following terms is used to describe a drug that has the same effect on a receptor as the endogenous chemical messenger?

a) agonist

b) antagonist

c) partial agonist

d) inverse agonist

Question 6

Which of the following statements best describes pharmacokinetics?

a) the study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by absorption, distribution, metabolism and excretion.

b) the study of how drugs can be designed using molecular modelling based on drug's pharmacophore.

c) the study of how a drug interacts with its target binding site at the molecular level to produce a particular pharmacological effect.

d) the study of which functional groups are important to a drug's activity, and the identification of a pharmacophore.

Question 7

What is meant by ADME in pharmacokinetics?

a) Affinity, dosage, marketing, efficacy

b) Absorption, distribution, metabolism, excretion

c) Agonism, dependence, mobility, efficiency

d) Antagonism, deficiency, mean, efflux

Question 8

Which of the following is one of the rules in Lipinski's rule of five?

a) A molecular weight equal to 500

b) No more than five hydrogen bond acceptor groups

c) No more than 10 hydrogen bond donor groups

d) A calculated logP value less than +5

Question 9

Which of the following statements is false regarding the blood brain barrier?

a) The walls of the capillaries supplying the brain have
tight fitting cells making it difficult for polar drugs
to leave the capillaries

b) The capillaries in the brain have a fatty coating making it more difficult for drugs to enter the brain

c) The walls of the capillaries supplying the brain are made up of several layers of cells, which act as a barrier to the release of drugs

d) Hydrophobic drugs pass through the blood brain barrier more easily than hydrophilic drugs

Question 10

What term is used to signify a preparation that appears identical to the preparation of an active drug but which has no biological activity?

a) Dummy drug

b) Peptidomimetic

c) Placebo

d) Gazebo

Which statement best describes information that must be included in a consent form quizlet?

Which of the following statements most accurately describes the review process for grant proposals?

Which of the following best described when a protocol may be eligible for expedited review by the IRB?

Which of the following laws relates most directly to the use animals in research and education?